Zsolt Sarang

Current appointment:

Senior  lecturer of biochemistry and molecular biology

Department of Biochemistry and Molecular Biology, Apoptosis signal research group (2005-)

Contacts:

Life Science Building, Egyetem tér 1., Debrecen, Hungary H-4010

Phone: +36-52-416-432/64789

Fax: +36-52-314-989

General information:

Languages:

Hungarian (native)

English (fluent, State Exam,)

German (fair)

Academic backgroud:

Ph.D. certificate

University of Debrecen, Debrecen  (2005)

  Title of Ph.D. thesis

Study of apoptosis and phagocytosis in the absence of tissue transglutaminase. Role of extracellular matrix-related proteins in the growth and migration of oral keratinocytes

Ph.D. student at:

Department of Biochemistry and Molecular Biology, Debrecen, Hungary

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Experiences abrod:

One month research work at the Institute of Immunology, Chung Shan Medical University, Taichung, Taiwan, 2007

Two years Ph.D studies az Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 
2001-2003

Current memberships in professional societies:

Hungarian Biochemical Society , Member since 2003

Awards

Bolyai János Research Scholarship (Hungarian Academy of Sciences 2007-2009)

Szodoray Lajos Scholarship (University of Debrecen 2011-2014)

Publications: 

20. 

Johnsen EO, Frøen RC, Albert R, Omdal BK, Sarang Z, Berta A, Nicolaissen B, Petrovski G, Moe MC. Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy.    
Exp Eye Res. 2012 May;98:28-36. Epub 2012 Mar 21.

19. 

Ruggiero L, Sarang Z, Szondy Z, Finnemann SC. αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.  
Adv Exp Med Biol. 2012;723:731-7. 

18.

Köröskényi K, Duró E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.
J Immunol. 2011 Jun 15;186(12):7144-55. Epub 2011 May 18.

17.

Z Sarang, K Köröskényi, A Pallai, E Duró, G Melino, M Griffin, L Fésüs, Z Szondy
Transglutaminase 2 Null Macrophages Respond to Lipopolysaccharide Stimulation by Elevated Proinflammatory Cytokine Production due to an Enhanced avb3 Integrin-induced Src Tyrosine Kinase Signaling
Immunol Lett. 2011 Jul;138(1):71-8. Epub 2011 Mar 21.

16.

Balogh Z, Fóris G, Kónya G, Paragh G Jr, Köbling T, Padra JT, Sarang Z, Paragh G
Obesity abrogates the concentration-dependent effect of leptin on endogenous cholesterol synthesis in human monocytes.
IMMUNOBIOLOGY (ISSN: 0171-2985) 216: (3) pp. 431-435. (2011)

15.

Tóth K, Sarang Z, Scholtz B, Brázda P, Ghyselinck N, Chambon P, Fésüs L, Szondy Z
Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription.
CELL DEATH AND DIFFERENTIATION (ISSN: 1350-9047)  (2010)

14.

Hodrea J, Demeny MA, Majai G, Sarang Z, Korponay-Szabo IR, Fesus L
Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages.
IMMUNOLOGY LETTERS (ISSN: 0165-2478) 130: (1-2) pp. 74-81. Paper 20005901. (2010)

13.

Toth B, Sarang Z, Vereb G, Zhang A, Tanaka S, Melino G, Fesus L, Szondy Z
Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophages.
IMMUNOLOGY LETTERS (ISSN: 0165-2478) 126: (1-2) pp. 22-28. Paper 19643138. (2009)

12.

Tóth B, Garabuczi E, Sarang Z, Vereb G, Vámosi G, Aeschlimann D, Blaskó B, Bécsi B, Erdődi F, Lacy-Hulbert A, Zhang A, Falasca L, Birge RB, Balajthy Z, Melino G, Fésüs L, Szondy Z
Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells
JOURNAL OF IMMUNOLOGY (ISSN: 0022-1767) 182: (4) pp. 2084-2092. (2009)

11.

Sarang Z, Tóth B, Balajthy Z, Köröskényi K, Garabuczi E, Fésüs L, Szondy Z
Some lessons from the tissue transglutaminase knockout mouse.
AMINO ACIDS (ISSN: 0939-4451) 36: (4) pp. 625-631. Paper 18584284. (2008)
10.

Sarang Z, Mádi A, Koy C, Varga S, Glocker MO, Ucker DS, Kuchay S, Chishti AH, Melino G, Fésüs L, Szondy Z
Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes.
CELL DEATH AND DIFFERENTIATION (ISSN: 1350-9047) 10: pp. 1842-1844. Paper 17612588. (2007)

9.

Majai G, Sarang Z, Csomos K, Zahuczky G, Fésüs L
PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells.
EUROPEAN JOURNAL OF IMMUNOLOGY (ISSN: 0014-2980) 37: (5) pp. 1343-1354. Paper 17407194. (2007)

8.

Sarang Z, Molnár P, Németh T, Gomba S, Kardon T, Melino G, Cotecchia S, Fésüs L, Szondy Z
Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice
HEPATOLOGY (ISSN: 0270-9139) 42: (3) pp. 578-587. (2005)

7.

Szondy Z, Sarang Z, Molnár P, Németh T, Piacentini M, Mastroberardino P G, Falasca L, Aeschlimann D, Kovács J, Kiss I, Szegezdi E, Lakos G, Rajnavölgyi E, Melino G, Fésüs L
TGase2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity
TISSUE ANTIGENS (ISSN: 0001-2815) 64: (4) pp. 342-343. (2004)
Nyelv: Angol
Absztrakt és egyéb folyóiratban/(i) Abstract/Tudományos [1026315] WOS (2006-08-25 00:00:00)  
1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), OCT 03-07, 2004., Budapest, HUNGARY

6.

Szondy Z, Sarang Z, Molnár P, Németh T, Piacentini M, Mastroberardino PG, Falasca L, Aeschlimann D, Kovács J, Kiss I, Szegezdi E, Lakos G, Rajnavölgyi E, Birckbichler PJ, Melino G, Fésüs L
Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN: 0027-8424) 100: (13) pp. 7812-7817. (2003)

5.

Hansson A, Bloor BK, Sarang Z, Haig Y, Morgan PR, Stark HJ, Fusenig NE, Ekstrand J, Grafstrom RC
Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes.
EUROPEAN JOURNAL OF ORAL SCIENCES (ISSN: 0909-8836) 111: (1) pp. 34-41. Paper 12558806. (2003)

4.

Sarang Z, Haig Y, Hansson A, Vondracek M, Warngard L, Grafstrom R
Microarray assessment of fibronectin, collagen and integrin expression and the role of fibronectin-collagen coating in the growth of normal, SV40 T-antigen-immortalised and malignant human oral keratinocytes.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS (ISSN: 0261-1929) 31: (6) pp. 575-585. Paper 15560747. (2003)

3.

Dressler D, Sarang Z, Szondy Z, Engelhart K, Grafstrom RC
Expression of retinoid-related genes in serum-free cultures of normal, immortalized and malignant human oral keratinocytes.
INTERNATIONAL JOURNAL OF ONCOLOGY (ISSN: 1019-6439) 20: (5) pp. 897-903. Paper 11956581. (2002)

2.

Vondracek M, Weaver DA, Sarang Z, Hedberg JJ, Willey JC, Warngard L, Grafstrom RC
Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.
INTERNATIONAL JOURNAL OF CANCER (ISSN: 0020-7136) 99: (6) pp. 776-782. Paper 12115477. (2002)

 1.

Hedberg JJ, Grafstrom RC, Vondracek M, Sarang Z, Warngard L, Hoog JO
Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes.
CELLULAR AND MOLECULAR LIFE SCIENCES (ISSN: 1420-682X) 58: (11) pp. 1719-1726. Paper 11706998. (2001)