László Nagy

Current appointment(s):

Professor of Biochemistry and Molecular Biology, 
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary 
(2006-)

Head of Debrecen Clinical Genomics Center  
(2000-)

Adjunct Professor of Pharmacology and Physiology 
Department of Integrative Biology Pharmacology and Physiology 
University of Texas-Houston, Medical School, Houston Texas, USA 
(1999-)

 International Research Scholar of the Howard Hughes Medical Institute 
(2001-2010)

Wellcome Trust International Senior Research Fellow
(2005-2009)

Contacts:

Office address: 

  Phone: +36-52-416432

Fax: +36-52-314989

Skype:

Email: lnagy(at)indi.biochem.dote.hu 

Web site: http://nlab.med.unideb.hu

General information:

Languages:

Hungarian (native)

English (State Exam, Advanced Level A025784 #019455, 2000)

Russian (State Exam, Intermediate Level # A 096533/1987)

Academic background:

Retinoid regulated gene expression during differentiation and apoptosis, Molecular analysis of the promoter of the mouse tissue transglutaminase gene 
Thesis for the degree of Ph.D. in Medical Sciences (cell and molecular biology) 
University Medical School of Debrecen, Debrecen, Hungary (1995)  

Ph.D. Student, in Medical Sciences (cell and molecular biology)University Medical School, Debrecen, Hungary(1992-1995)Advisors: Peter J.A. Davies, Ph.D, University of Texas-Houstonand László Fésüs, Ph.D, University Medical School of Debrecen

Programmed cell death in malignant cell lines in vitro
Thesis for the degree of M.D. (in Hungarian)
University Medical School of Debrecen, Debrecen, Hungary (1989)  

Medical Student, University Medical School, Debrecen, Hungary(including one year internship in 1991)(1985-1991) 

Scientific background:

Associate Professor of Biochemistry and Molecular Biology,
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary 
(2000-2006)

Young Investigator of the European Molecular Biology Organization (EMBO) 
(2001-2004)

Assistant Professor of Biochemistry and Molecular Biology,
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary 
(1999-2000)  

Postdoctoral Associate,
Gene Expression Laboratory, The Salk Institute for Biological Studies , La Jolla, USA 

Special Fellow of the Leukemia Society of America (1998-1999) 
Postdoctoral Fellow of the Howard Hughes Medical Institute (1997-1998) 
Advisor: Ronald M. Evans, Ph.D.
(1996-1999)

Instructor in Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology, University medical School of Debrecen, Hungary (1995-1999)  

Postdoctoral Fellow,
Department of Pharmacology, University of Texas, Houston, Medical School, USA

Advisor: Peter J.A. Davies M.D., Ph.D.

(1992-1995) 

Research Fellow of the Hungarian Academy of Sciencies, 
Department of Biochemistry, University Medical School, Debrecen, Hungary. 
Advisor: László Fésüs M.D., Ph.D. 
(1991-1992) 

Current memberships in professional societies:

Hungarian Biochemical Society, Member since 1989. 
Hungarian Chamber of Physicians, Member since 1994. 
Society of Pro Scientia Gold Medal Laureates, Member since 1995. 
Endocrine Society (USA), Active Member since 2002 
European Macrophage and Dendritic Cell Society, Member since 2002 
American Society of Biochemistry and Molecular Biology, Member since 2003 
Hungarian Society for Bioinformatics, Founding member, executive committee member since 2006

Awards:

Wellcome Trust International Senior Research Fellow (2005-2009)

Széchenyi Istvan Fellowship (2003-2006)

EMBO Young Investigator (2000-2004)

Howard Hughes Medical Institute International Research Scholar (2000-2010)

Ranked as #5 scientist in 1999 based on the number of highly cited, "Hot papers" published in 1997-1998 (Institute for Scientific Information Hot papers Database)

Széchenyi Professorship (1999-2002) 

Boehringer Ingelheim Research Award (1999)

Cheryl Whitlock/Pathology Prize, Stanford University (1998)

Weszprémi-Prize for Outstanding Academic and Scientific Activity presented by the Rector of the University Medical School of Debrecen (1991)

Outstanding Tutor in Biology University Medical School of Debrecen (1989)

Pro Scientia Gold Medal for Outstanding Scientific Achievements presented by the President of the Hungarian Academy of Sciences (1989)

Publications:

2006

43. Rethi, B., Gogolak, P., Szatmari, I., Veres, A., Nagy, L., Rajnavolgyi, E., Terhorst, C. and Lanyi, A. SLAM/SLAM interactions inhibit CD40 induced production of inflammatory cytokine in monocyte derived dendritic cells Blood 107: 2821-2829 (2006)

44. Balint, L. B. and Nagy, L.  Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases Endocrine, Metabolic and Immune Disorders-Drug Targets 6:33-43 (2006) INVITED REVIEW

45. Nagy, L., Schüle,R., and Gronemeyer, H.  Twenty years of nuclear receptors (Meeting report) EMBO Reports 7(6): 579-584 (2006)

46. Szatmari, I., Rajnavolgyi, E. and Nagy, L.  PPARg, a lipid activated transcription factor as a regulator of dendritic cell function Annals of the New York Academy of Sciences (in press) (2006) INVITED REVIEW

47. Szekvolgyi, L., Balint L.,B., Imre, L., Goda, K., Szabo, M., Nagy, L., and Szabo, G., ChIP on-beads: a robust flow-cytometry based method for the evaluation of chromatin immunoprecipitation resultsCytometry (in press) (2006)

48. Szeles, L., Torocsik, D. and Nagy, L.  At the crossroad of lipid metabolism and inflammation B.I.F. Futura (Boehringer Ingelheim Funds) 21:79-85 (2006) INVITED REVIEW

49. Szatmari, I, Vamosi, G., Brazda, P., Balint L. B., Benko, S., Szeles, L., Jeney, V., Özvegy-Laczka, G., Szanto, A., Barta, E., Balla, J., Sarkadi, B. and Nagy, L. PPARg reguleted ABCG2 expression confers cytoprotection to human dendritic cells Journal of Biological Chemistry 281:23812-23823 (2006)

50. PPARg controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells Szatmari, I., Pap, A., Ruehl, R., Ma, J.X., Illarionov, P.A., Besra, G.S., Rajnavolgyi, E., Dezso, B. and Nagy, L.  Journal of Experimental Medicine (in press) (2006)

 2005

35. Szanto, A and Nagy, L.  Retinoids potentiate PPAR-gamma action in differentiation, gene expression and lipid metabolic processes in developing myeloid cells Molecular Pharmacology 67(6):1935-1943 (2005)

36. Balint L. B., Szanto, A., Madi, A., Bauer, U-M., Gabor, P., Benko, S., Puskas, L., Davies, P.J.A. and Nagy, L.  Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells Molecular and Cellular Biology 25:5648-5663 (2005)

37. Balint L. B., Gabor, P. and Nagy, L.  Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell line. Immunobiology 210:141-152 (2005)

38. Kappelmayer, J., Simon, A., Katona, E., Szanto, A., Nagy, L., Kiss, A., Kiss, Cs. and Muszbek, L. Flow cytometric detection of intracellular coagulation factor XIII-A: its utilization in the diagnosis and monitoring of monocytic acute myeloid leukemias. Thrombosis and Heamostasis 94(2):454-459 (2005)

39. Torocsik, D., Bardos, H., Nagy, L. and Adany, R.  Opposite expression of Factor XIII-A gene in classical and alternative activation of macrophages Cellular and Molecular Life Sciences 62:2132-2139 (2005)

40. Nagy, L. and Spiteller, G. Atherosclerosis and lipid peroxidation (Editorial) Molecular Nutrition and Food Research 49: 989-991 (2005) EDITORIAL

41. Nagy, L. and Szanto, A. Roles for lipid activated transcription factors Molecular Nutrition and Food Research 49:1072-1074 (2005) INVITED REVIEW

2004

31. Nagy, L. and Schwabe J.W.R.  The mechanism of nuclear receptor molecular switch Trends in Biochemical Sciences 29(6):317-324 (2004)

32. Szatmari, I., Gogolak, P., Im, S. J., Dezso, B., Rajnavolgyi, E. and Nagy, L.  Activation of PPAR-gamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion Immunity21:95-106 (2004)

33. Szanto, A., Benko, S., Szatmari, I., Balint, L.B., Furtos, I., Rühl, R., Molnar, S., Csiba, L., Garuti, R., Calandra, S., Larsson, H., Diczfalusy, U. and Nagy, L.  Transcriptional regulation of human CYP27 integrates retinoid, PPAR and LXR signaling Molecular and Cellular Biology 24(18):8154-8166 (2004)

2003

29. Ahuja, A.S., Szanto, A., Nagy, L. and Davies, P.J.A. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death Journal of Biological Regulators and Homeostatic Agents 17:29-45 (2003) INVITED REVIEW

2002

27. Love, J.D., Gooch, J.T., Benko, S., Nagy, L., Chatterjee, V.K.K., Evans,, R.M. and Schwabe, J.W.R. The structural basis for the specificity of retinoid-X-receptor selective agonists: new insights into the role of helix H12. Journal of Biological Chemistry 277(13):11385-11391 (2002)

2001

24. Chawla, A., Barak, Y., Nagy, L., Liao, D. Tontonoz, P., and Evans, RM  PPARg dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation Nature Medicine7(1):48-53 (2001)

25. Ahuja, HS, Crombie, DL, Boehm, M,Leibowitz, MD, Heyman, RA, Depre, C, Nagy, L., Tontonoz, P and Davies, P.J.A. Tissue specific effects of RXR and PPAR-gamma ligands on metabolic gene expression in diabetic rodents Molecular Pharmacology 59 (4) 765-773 (2001)

26. Chawla, A, Boisvert, W.A., Lee, C-H., Laffitte, B., Barak, Y., Joseph, S.B., Nagy, L., Liao, D., Edwards, P.A., Curtiss, L.K., Evans, R.M., and Tontonoz , P. A PPARg-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Molecular Cell 7: 161-171 (2001) 

 2000

21. Love, J.D., Gooch, J.T., Nagy, L., Chatterjee, V.K.K. And Schwabe, J.W.R  Transcriptional repression by nuclear receptors: mechanisms and role in disease Biochem. Soc. Trans. 28: 390-396 (2000) INVITED REVIEW

22., Lee, H, Shi, W, Tontonoz, P, Wang, S, Subbanagounder, G., Hedrick, L., Hama, S., Borromeo,C., Evans, RM., Berliner, JA and Nagy, L.  A role for PPARa in oxidized phospholipid induced synthesis of MCP-1 and IL-8 by endothelial cells Circulation Research 87: 516-521 (2000)

16. Tontonoz, P.*, Nagy, L.*, Alvarez, JGA., Thomazy, VA. and Evans, RM. PPARg promotes monocyte/macrophage differentiation and uptake of oxidized LDL Cell 93(2): 241 - 252 (1998) 
* joint first authors

10. Nagy, L., Thomazy, A.V., Saydak, M.M., Stein, J.P. and Davies, P.J.A. The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid regulated and apoptosis linked expression Cell Death and Differentiation 4 (7): 534-547 (1997)

6. Yan, H- Z., Noonan, S., Nagy, L., Davies, P.J.A. and Stein, J.P. Retinoic acid induction of the tissue transglutaminase promoter is mediated by a novel response element Molecular and Cellular Endocrinology 120: 203-212 (1996)