Current appointment(s):
Professor of Biochemistry and Molecular Biology,
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary (1991-)
Head of Department of Biochemistry and Molecular Biology
(1997-)
Rector of the University of Debrecen
(2007-2010)
Contacts:
Office address:
Life Science Building, Egyetem tér 1., Debrecen, Hungary H-4010
Phone: +36-52-416432
Fax: +36-52-314989
Skype:
Email: fesus(at)indi(dot)biochem(dot)dote(dot)hu
General information:
Languages:
Hungarian
English
Research and academic position:
President of the Medical and Health Science Center, University of Debrecen (2001-2004, 2004-2007)
Rector of the University of Debrecen (2000-2001)
Rector of the University of Medical School Debrecen (1999)
Vice Rector for Science, University of Medical School of Debrecen (1995-1998)
6 month visiting professorship, 2nd University of Rome, "Tor Vegata", Department of Biology (1991)
Full-Professor of Biochemistry, Department of Biochemistry and Molecular Biology, University Medical School of Debrecen (1991-
Professor, Department of Biochemistry and Molecular Biology, University Medical School of Debrecen (1987-1990)
4 month visiting professorship, Universtiy of Texas Medical School at Houston, Department of Pharmacology (1989)
Associate professor, Department of Biochemistry and Molecular Biology, Universtiy Medical School of Debrecen, (1986-1987)
Associate professor, Department of Biophysics, Universtiy Medical School of Debrecen, (1985-1986)
Visiting Scientist, National Institutes of Health, Bethesda, Md. USA, NIDR, LOBP, Section of Molecular Enzymology (1983-1985)
Associate Professor, Head of Enzymology Section, Department of Clinical Chemistry, University Medical School of Debrecen (1976-1977)
Visiting Fellow, National Institutes of Health, Bethesda Md. USA, NIAMID (1976-1977)
Membership in the Management of Hungarian Scientific Societies:
Executive Committee of the Hungarian Biochemical Society (1985-, newly elected in 1990 and in 1995) president of the Society (2005-)
Executive Committee of the Cell Biology Section of the Hungarian Biologist Society (1986-) President of the Section (1993, newly elected for 1997)
Executive Committee of the Hungarian Laboratory Diagnostical Society (1985-1990)
Executive Committee of the Hungarian Immunology Society (1985-1990)
Member of the Széchenyi Professor Fellowship Committee (1996-1997)
Member of the Sponzoring Committee of Higher Education Scientific Coucil
Member of the Accreditation Visiting Committee of POTE and SZOTE
President of the Individual Biology Committe of OTKA (1997-2001)
President of the Hungarian Accreditation Committee (2004-2007)
Hungarian Academy of Sciences:
Member of the Biochemistry and Molecular Biology Committee (Department of Biological Sciences)
Member of the Cell- and Evolution Biology Committe (1990-), secretary (1990-1997), president (1997-2003)
Consulting Member of the Department of Biological Sciences (1993-1998)
Corresponding Member of the Hungarian Academy of Sciences, Department of Biological Sciences (1993-1998)
Member of the Hungarian Academy of Sciences (2004-)
Membership in International Organizations:
Member of the Executive Committee of "European Cell Death Organization (1993-)"Elected President 1997-1999
Vice President of "European cell Biology Organization" (1995-2000)
Leader of COST 844 Apoptosis Program (2000-2005, 18 countries)
President of European Science Foundation "Translutaminases and Protein Cross-linking reaction" programme (2000-2005)
Editorial Positions:
Clinical Chemisty and Enzymology Communications (1987-1999)
Cell Death and Differentiation (1993-2005)
Scientific Students' Society
Topic instructor in dissertations 12 occasions
"Master of Topic Leader" (1993) elected by rhe Council of Scientific Students' Society
Ph.D. programme
Leader of the accreditated Ph.D. programme: Studying of the Molecular Function of Cells and Tissues in Healthy and Pathological Cases.
Number of collaborators, acquiring Ph.D. degree: 11.
Awards:
"Hungarian Higher Educaton Plaquette" (1994)
Szent-Györgyi Prize (1996)
Tankó Béla Award (Award of the Hungarian Biochemical Society) (1997)
Pro Urbe Award of the City of Debrecen (2001)
Honour Plaquette of Debrecen University (2001)
Went István Plaquette (2002)
Széchenyi István Fellowship (2005)
Pro Renovada Cultura Hungariae (2006)
Pázmány Péter Higher Education Award (2006)
Hajós Alfréd díj (2007)
Semmelweis-díj (2008)
Publications
(2009)
Sarang, Zs., Tóth, B., Balajthy, Z.,Köröskényi, K., Garabuczi, É., Fésüs, L., Szondy, Zs.: Some lessons from the tissue transglutaminase knockout mouse Amino Acids 36 (4), 625-631
Tóth, B., Garabuczi, É., Sarang, Zs., Vereb, Gy., Vámosi, Gy., Aeschlimann, D., Blaskó, B., Bécsi, B., Erdődi, F., Lacy-Hulbert, A., Zhang, A., Falasca, L., B.Birge, R., Balajthy, Z., Melino, G., Fésüs, L., Szondy, Zs.: Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells Journal of Immunology 182 (4), 625-31
Beck, Z., Kis, A., Berényi, E., Kovács, P., Fésüs, L., Aradi, J.: 4-Thio-uridylate (UD29) interferes with the function of protein –SH and inhibits HIV replication in vitro Pharmacological reports 61, (343-347)
Csősz, E., Meskó, B., Fésüs, L.:Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface Amino Acids 36 (4) 615-617 Nemes, Z., Fésüs,.L.:Methods to Analyze Transglutamination of Proteins Involved in Apoptosis Methods Mol. Biol.559, 107-116
Nemes, Z., Petrovski, G., Aerts, M., Sergeant, K., Devreese, B., Fésüs, L.:Transglutaminase-mediated intramolecular cross-linking of membrane-boundalpha-synuclein promotes amyloid formation in Lewy bodies. J Biol Chem. (40), 27252-27264
(2008)
Kiss, I., Rühl, R., Szegezdi, É., Fritzsche, B., Tóth, B., Pongrácz, J., Perlmann, T., Fésüs, L., Szondy, Zs.(2008): Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development. Eur. J. Immunol. 38, 147-55
Korponay-Szabó, IR., Vecsei, Zs., Király, R., Dahlbom, I., Chirdo, F., Nemes, É., Fésüs, L., Mäki, M.(2008): Deamidated gliadin peptides form epitopes that transglutaminase antibodies recognize J. Ped. Gastr. Nutr. 46 (3), 253-61
Csősz, E., Bagossi, P., Nagy, Z., Dosztányi, Zs., Simon, I., Fésüs, L. (2008):Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examination. J Mol Biol. 383 (2), 390-402
Bursch, W., Karwan, A., Mayer, M., Dornetshuber, J., Fröhwei, U., Schulte-Hermann, R., Fazi, B., Di Sano, F., Piredda, L., Piacentini, M., Petrovski, G., Fésüs, L., Gerner, C.(2008): Cell death and autophagy. Toxicology254 (3), 147-57
Pócsi, I., Jeney, V., Kertai, P., Pócsi, I., Emri, T., Gyémánt, G., Fésüs L., Balla, J., Balla, G.(2008): Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food. Mol. Nutr. Food Res. 52 (12) 1434-47
(2007)
Petrovski, G., Zahuczky, G., Katona, K., Vereb, G., Martinet, W., Nemes, Z., Bursch, W., Fesus, L., (2007):Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes. Cell Death Differ.14, 1117-28.
Majai, G., Sarang, Z., Csomos, K., Zahuczky, G., Fésüs, L., (2007): PPARgamma-dependent regulation of human macrophages in phagocytosis of apopototic cells. Eur.J.Immunol. 37, 1343-54.
Sarang, Z., Mádi, A., Koy, C., Varga, S., Glocker, MO., Ucker, DS., Kuchay, S., Chisthi, AH., Melino, G., Fésüs, L., (2007): Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpan activity in calcium-induced death of erythrocytes. Cell Death Differ. 14, 1842-4.
Petrovski, G., Zahuczky, G., Majai, G., Fésüs, L.,(2007): Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages. Autophagy 3, 509-1.
(2006)
Mádi, A., Kárpáti, L., Kovács, A., Muszbek, L. Fésüs, L., (2006): High-throughput scintillation proximity assay for transglutaminase activity measurement. Analytical Biochemistry 343, 256-262.
Katona, K., Herczegh, P., Kappelmayer, J., L.Fésüs, L., Aradi, J., (2006): Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells. Cancer Letters 235, 281-290.
Kiraly, R, Vecsei, Z, Demenyi, T, Korponay-Szabo, IR and Fesus, L, (2006) Coeliac autoantibodies can enhance transamidating and inhibit GTPase activity of tissue transglutaminase: dependence on reaction environment and enzyme fitness. J Autoimmun 26: 278-87.
Kiss, I.,Oskolás, H., Tóth, R., Bouillet P.,Tóth, K., Fülöp, A., Scholtz, B.,Ledent, C., Fésüs, L., and Szondy, Z., (2006): Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. Eur. J. Immunology 36, 1559-71
Szondy, Z., Mastroberardino, PG., Váradi, J.,Farrace, MG., Nagy, N., Bak, I., Viti, I., Wieckowski, MR., Melino, G., Rizzuto, R. Tósaki, Á., Fesus, L. ,M. Piacentini(2006): Tissue transglutaminase (TG2) protects cardiomyocytes against ischemia/reperfusion injury by regulating ATP synthesis Cell Death an Differentiation 10, 1827-9
Balajthy, Z., Csomós, K., Vámosi, Gy., Szántó, A., Lanotte, M., and Fésüs, L, (2006): Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions. Blood 108, 2045-54
Keresztessy, Z., Csősz, E., Hársfalvi, J., Csomos, K., Gray, J., Lightowlers, R.N., Lake, J.H., Balajthy, Z., Fésüs, L, (2006): Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2. J.Protein Sci. 11, 2466-80
Majai, G., Petrovski, G., Fesüs, L., (2006): Inflammation and the apopto-phagotic system. Immunol Lett. 104, 94-101.
Fésüs, L., Szondy, Zs.: 13th Euroconference on apoptosis Cell Death Differ. 7. 242-4 (2006).
(2005)
Korponay-Szabó, I., Raivio, T., Laurila, K., Opre,J., Király, R., Kovács, JB., Kaukinen, K. Fésüs,L.,Maki, M., (2005): Coeliac disease case finding and diet monitoring by point-of-care testing. Aliment Pharmacol. Ther. 22, 729-732Horváth, A., Tőkés, Sz., Hartman, T., Watson, K., Turpin, JA., Buckheit Jr.,RW., Sebestyén, Zs., Szöllősi, J., Benkő, I., Bardos, TJ.,J. Dunn,JA., Fésüs, L., Tóth, FD., Aradi, J., (2005): Potent inhibition of HIV-1 entry by (s4dU)35. Virology 334, 214-223Ludányi, K., Nagy, Zs,S., Alexa, M., Reichert,U., Michel, S.,Fésüs, L., and Szondy, Zs., (2005): Ligation of RARg inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels.Immunology Letters 98, 103-113Sarang, Zs., Molnár,P., Németh, T., Gomba,Sz., Kardon,T., Melino,G., Cotecchia,S.,Fésüs, L., and Szondy, Zs., (2005): Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death. Hepatology 42, 578-587Fésüs, L.,Szondy, Zs., (2005): Transglutaminase 2 in the balance of cell death and survival. FEBS Letters 579, 3297-3302.
(2004)
Korponay-Szabó, IR., Halttunen, T., Szalai, Z., Laurila, K., Király, R.,Kovács, JB., Fésüs, L., Maki, M., (2004): In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 53, 641-648Mádi, A., Hoffrogge, R., Blaskó, B., Glocker MO., and Fésüs, L., (2004): Identification of amine donor protein substrates for transglutaminase activity in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 315, 1064-1069Blaskó, B., Mádi, A., Fésüs, L (2003): Structural elements responsible for transglutaminase activity of protein disulphide isomerases and thioredoxins. J. of Biological Regulators and Homeostatic Agents 18, 1-8Tóth, B.,Kis-Tóth, K.,IKiss, I., Reichert,U., Michel, S.,Fésüs, L.,Szondy, Zs., (2004): Retinoids induce Fas(CD95) ligand cell surface expression via RARg and Nur77 in T cells. Eur. J. Immunology 34, 827-836Nemes, Z., Devreese, B., Steinert, P.M., vanBeeumen, J. and Fésüs, L (2004): Identification of Ne(g-glutamyl)lysine crosslinks in intraneuronal inclusions of human brain specimen. FASEB J. 1135-1145Davids, B.J., Mehta, K., Fesus, L., McCaffery, J.M., Gillin, F,D. (2004): Dependence of Giardia lamblia encystation on novel transglutaminase activity. Mol. Biochem. Parasitol. 136, 173-180
(2003)
Blaskó, B., Mádi, A., Fésüs, L (2003): Structural elements responsible for transglutaminase activity of protein disulphide isomerases and thioredoxins. J. of Biological Regulators and Homeostatic Agents 18, 1-8Korponay-Szabó, IR., Laurila,K.,Szondy, Zs., Halttunen,T., Szalai, Z., Dahlbom, I. Rantala, J., Kovács, B., Fésüs,L., Maki, M.,(2003): Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues. GUT 52, 199-204 Mádi, A., Pusztahelyi, T.,Punyiczki, M., and Fésüs, L., (2003): The biology of the post-genomic era: the proteomics (review). Acta Biologica Hungarica 54, 1-14Blaskó, B., Mádi, A. and Fésüs, L (2003): Thioredoxin motif of Caenorhabditis elegans PDI-3 provides Cys and His catalytic residues for transglutaminase activityBiochemical and Biophysical Research Communications 303, 1142-1147Szondy, Zs., Sarang, Zs., Molnár, P., Németh, T., Piacentini, M., Mastroberardio, P.G., Falasca, L., Aeschlimann, D., Kovács, J., Kiss, I., Szegezdi, E., Lakos, G., Rajnavölgyi, É., Birckbichler, P.J., Melino, G. and Fésus, L. (2003): TGASE2-/- mice reveal a crosstalk between apoptotic cells and macrophages during the apopto-phagocytotic program. Proc. Natl. Acad. Sci. USA 100, 7812-7817Szegezdi, É., Kiss, I., Simon, Á., Blaskó, B., Reichert, U., Michel, S., Sándor, M., Fésüs, L and Szondy, Zs. (2003): Ligation of retinoic acid receptor a regulates negative selection of thymocytes by inhibiting both DNA binding ofnur77 and synthesis of Bim 1. Journal of Immunology 170, 3577-3584
(2002)
Apoptózis (Szerk.: Kopper László, Fésüs László)Medicina Könyvkiadó Rt.Fésüs László, Tóth Réka, Mádi András)18. fejezet (415-428. old.) Az apoptózis mint terápiás célpont (Fésüs László, Fenyőfalvi György) 2002 1. fejezet (15-32. old.) Az apoptóziskutatás története (Bursch, W., Fesus, L. (2002): 9th Euroconference on apoptosis. Cell Death and Differentiation 9, 696-698Fesus, L., Piacentini, M. (2002): Transglutaminase 2: an enigmatic enzyme with diverse funcions. TIBS 27, 534E. Csosz, Z. Keresztessy, L. Fesus: Transglutaminase substrates: from test tube experiments to living cells and tissues. Minerva Biotechnologica 14, 149-153 (2002)Mónika Sárvári, László Fésüs and Zoltán Nemes: Transglutaminase-mediated crosslinking of neural proteins in Alzheimer's disease and other primary dementias.Drug Development Research 56, 458-472 (2002)Sárvári, M., Deli, L., Fésüs, L, Kárpáti, L., Muszbek, L., Nemes, Z.(2002): Competitive ELISA assay for Ne(g-glutamyl)lysine. Anal. Biochem. 311(2), 187-190 A. Amendola, L. Fésüs, M. Piacentini, Zs. Szondy (2002): „Tissue" transglutainase inAIDS. Journal of Immunlogical Methods 265, 145-159P.G. Mastroberardino, C. Iannicola, R. Nardacci, F. Bernassola, V. De Laurenzi, G. Melino, S. Moreno, F. Pavone, S. Oliverio, L. Fesus and M. Piacentini (2002): „Tissue" transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's diseaseCell Death and Differentiation 9, 873-880
(2001)
Gáspár, R., Bagossi, P., Bene, L., Matkó, J., Szöllősi, J., Tőzsér, J., Fésüs, L, Waldmann, T.A., and Damjanovich, S. (2001): Clustering of class I HLA oligomers with CD8 and TCR: Three-dimensional models based on fluorescence resonance energy transfer and crystallographic data.The Journal of Immunology 166, 5078-5086
Nemes, Z., Fésüs, L, Égerházi, A., Keszthelyi, A, Degrell, I.M. (2001): e(g-glutamyl)lysine in cerbrospinal fluid marks Alzheimer type and vascular dementia.Neurobiol. Aging 22, 403-406Uray, I., Davies, P.J.A. and Fésüs, L (2001): Pharmacological separation of the expression of tissue transglutaminase and apoptosis after chemotherapeutic treatment of HpG2 cells. Molecular Pharmacology 59, 1388-1394Ambrus, A. and Fésüs, L (2001): Polyethylene glycol enhanced refolding of the recombinant human tissue transglutaminase. Prep. Bichem. and Biotechnol. 31, 59-70Mádi, A., Kele, Z., Janáky, T., Punyiczki, M. and Fésüs, L (2001): Identification of protein substrates for transglutaminase in Caenorhabditis elegans. Biochemical and Biophysical Research Communications 283, 964-968Ambrus, A., Bányai, I., Weiss, M.S., Hilgenfeld, R., Keresztessy, Zs., Muszbek, L. and Fésüs, L (2001): Calcium binding of transglutaminases: A 43Ca NMR study combined with surface polarity analysis. J. of Biomolecular Structure and Dynamics 19, 59-74Ádám V., Dux L., Faragó A., Fésüs L, Machovich R., Mandl J., Sümegi, B. (2001): Orvosi biokémia (Szerk.: Ádám Veronika), Medicina Könyvkiadó Rt., BudapestToth, R., Szegezdi, E., Reichert, U., Bernardon, J.M., Michel, S., Ancian, P., Kis-Toth, K., Macsari, Z., Fesus, L., Szondy, Z. (2001): Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells.Eur. J. Immunol. 31, 1382-1391Szondy, Z., Toth, R., Szegezdi, E., Reichert, U., Ancian, P., Fesus, L. (2001): Cell death in HIV pathogenesis and its modulation by retinoids. Ann. N.Y. Acad. Sci. USA 946, 95-107
(2000)
Szegezdi, É., Szondy, Z., Nagy, L., Nemes, Z., Friis, R.R., Davies, P.J.A. and Fésüs, L (2000)Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter. Cell Death and Differentiation 7, 1225-1233Nemes, Z., Demény, M., Marekov, L.N., Fésüs, L, and Steinert, P.M. (2000): Cholesterol 3-sulfate interferes with cornified envelope assembly by diverting transglutaminase 1 activity from the formation of cross-links and esters to the hydrolysis of glutamine.The Journal of Biological Chemistry 275, 2636-2646
(1999)
Tóth, R., Szegezdi, É., Molnár, G., Lord, J.M., Fésüs, L and Szondy, Z. (1999): Regulation of all surface expression of Fas (CD95) ligand and susceptibility to Fas mediated apoptosis in activation - induced T cell death involve calcineuria and protein kinase c respectively.Eur. J. Immunol. 29, 383-393Mic, F.A., Molnar, P., Keresztes, T., Szegezdi, É., Fesus, L. (1999): Clearance of apoptotic thymocytes is decreased by inhibitors of eicosanoid synthesis (Letter to the Editor). Cell Death and Differentiation 6, 593-595Nemes, Z., Marekov, L.N., Fésüs, L and Steinert, P.M. (1999): A novel function for transglutaminase 1: Attachment of long-chain w-hydroxyceramides to involucrin by ester bond formation.Proc. Natl. Acad. Sci. USA 96, 8402-8407L. Fésüs (1999): Inducible gene expression in apoptosis. Cell Death and Differentiation 6, 1144-1145
(1998)
Fésüs, L (1998): Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes.Cellular and Molecular Neurobiology 18, 683-694Punyiczki, M. and Fésüs, L (1998): Stress and Apoptosis. Annals of the New York Academy of Sciences 851, 67-74Szondy, Z., Reichert, U. and Fésüs, L (1998): Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors. Cell Death and Differentiation 5, 4-10Szondy, Z., Reichert, U., Bernardon, J.M., Michel, S., Tóth, R., Karászi, É. and Fésüs, L (1998): Inhibition of activation-induced apoptosis of thymocytes by all-trans and 9-cis retinoic acid is mediated via retinoic acid receptor a.Biochem. J. 331, 767-774Mádi, A., Punyiczki, M., Di Rao, M., Piacentini, M. and Fésüs, L (1998): Biochemical characterization and localization of transglutaminase in wild-type and cell-death mutants of the nematode Caenorhabditis elegans.European Journal of Biochemistry 253, 583-590Szondy, Z., Lecoeur, H., Fésüs, L and Gougeon, M-L. (1998): All-trans retinoic acid inhibition of anti-CD3 induced T cell apoptosis in HIV infection mostly concerns T lymphocytes and is mediated via regulation of FasL expression.J. Infect. Dis. 178, 1288-1298
(1997)
Szondy, Z., Nemes, Z., Boyiadzis, M., Kedei, N., Toth, R. and Fésüs, L (1997): Differential expression of tissue transglutaminase in apoptosis induced via distinct signalling pathways. FEBS Letters 404, 307-313Szondy, Z., Reihert, U., Bernardon, J-M., Michel, S., Toth, R., Ajzner, E. and Fésüs, L (1997): Induction of apoptosis by retinoids and RARg selective compounds in mouse thymocytes through a novel apoptosis pathway. Molecular Pharmacology 51, 972-982Nemes, Z., Ádány, R., Balazs, M., Boross, P. and Fésüs, L (1997): Identification of cytoplasmic actin as an aboundant glutaminyl substrate for tissue transglutaminase in HL-60 and U-937 cells undergoing apoptosis.Journal of Biological Chemistry 272, 20577-20583Mádi, A., Punyiczki, M. and Fésüs, L (1997): Lessons to learn from the Ceanorhabditis elegans cell death genes. Acta Biologica Hungarica 48, 303-318Oliverio, S., Amendola, A., Di Sano, F., Farrace, M.G., Fésüs, L, Nemes, Z., Piredda, L., Spinedi, A. and Piacentini, M. (1997): Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis. Molecular and Cell Biology 17, 6040-6048Balajthy, Z., Kedei, N., Nagy, L., Davies, P.J.A. and Fésüs, L (1997): Lack of induction of tissue transglutaminase but activation of the preexisting enzyme in c-myc-induced apoptosis of CHO cells. Biochemical and Biophysical Research Communications 236, 280-284
Piredda, L., Amendola, A., Colizzi, V., Davies, P.J.A., Farrace, M.G., Fraziano, M., Gentile, V., Uray, I., Piacentini, M. and Fesus, L. (1997): Lack of 'tissue' transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: relationship to development of autoimmunity in MRLlpr/lpr mice. Cell Death and Differentiation 4, 463-472
(1996)
Nemes, Z., Friis, R., Aeschlimann, D., Saurer, S., Paulsson, M. and Fésüs, L (1996): Expression of tissue transglutaminase coincides with apoptotic cells in involuting rodent mammary tissue. European Journal of Cell Biology 70, 125-133Amendola, A., Gougeon, M.-L., Poccia, F., Fésüs, L and Piacentini, M. (1996): Tissue transglutaminase indicates high rate of apoptosis in the immune system of of HIV-infected individuals.Proceedings of the National Academy of Sciences, U.S.A. 93, 11057-11062Fésüs, L, Nemes, Z., Piredda, L., Madi, A., Di Rao, M. and Piacentini, M. (1996): Measurement of the induction, activity and products of tissue transglutaminase in cells undergoing apoptosis. In: "Apoptosis Techniques" (Cotter, T. and Martin, S., eds). Portland Press, London, pp. 21-49Fésüs, L, Madi, A., Balajthy, Z., Nemes, Z. and Szondy, Zs. (1996): Transglutaminase induction by various cell death and apoptosis pathways.Experientia 52, 942-949
(1995)
Fésüs, L, Szondy, Zs. and Uray, I. (1995): Probing the molecular program of apoptosis by cancer chemopreventive agents. Journal of Cellular Biochemistry 22, 151-161Nagy, L., Thomazy, V. A., Shipley, G.L., Fésüs, L, Lamph, W., Heyman, R.A., Chandraratna, R.A.S. and Davies, P.J.A. (1995): Activation of Retinoid X receptors (RXR) induces apoptosis in HL-60 cell lines.Molecular and Cell Biology 15, 3540-3551
(1994)
Piacentini, M., Davies, P.J.A. and Fésüs, L (1994): Tissue transglutaminase in cells undergoing apoptosis. In: "Apoptosis. The Molecular Basis of Cell Death" Current Communications in Cell and Molecular Biology. 3. (Tomei, L.D. and Cope, F.O., eds.) Cold Spring Harbor Laboratory Press. pp. 78-91Harsfalvi, J., Udvardy, M. and Fesus, L. (1994): Enzymatic fluorimetric assay for e(g-glutamyl)lysine isodipeptide. Fibrinolysis 8, 378-381
(1993)
Piacentini, M.., Fésüs, L and Melino, G. (1993): Multiple cell cycle access to the apoptotic death programme in human neuroblastoma cells. FEBS Letters 320, 150-154Fésüs, L (1993): Biochemical events in naturally occurring forms of cell death. FEBS Letters 328, 1-5Fésüs, L, Melino, G. and Piacentini, M. (1993): Apoptosis and carcinogenesis: a perspective through transglutaminase, one of the key participants in the molecular program of apoptosis. Clinical Chemistry and Enzymology Communications, 6, 1-6Hársfalvi, J., Tarcsa, E., Udvardy, M., Zajka, G., Szarvas, T. and Fésüs, L (1992): Presence and possible origine of e(g-glutamyl)lysine isodipeptide in human plasma. Thrombosis and Haemostasis 67, 60-62
(1992)
Piacentini, M., Ceru, M.P., Dini, L., Di Rao, M., Piredda, L., Thomazy, V., Davies, P.J.A. and Fésüs, L (1992): In vivo and in vitro induction of "tissue" transglutaminase in rat hepatocytes by retinoic acid. Biochimica et Biophysica Acta Mehta, K., Rao, U.R., Vickery, A.C. and Fésüs, L (1992): Identification of a novel transglutaminase from the filarial parasite Brugia malayi and its role in growth and development.Molecular and Biochemical Parasitology 53, 1-15Bursch, W., Fésüs, L and Schulte-Herman, R. (1992): Apoptosis ("Programmed" cell death) and its relevance in liver injury and carcinogenesis. In: "Tissue Specific Toxicity: Biochemical Mechanisms" (Dekant, W. and Neumann, H.G., eds) Academic Press, pp. 95-115Zatloukal, K., Fésüs, L, Denk, H., Tarcsa, E., Spurej, G. and Bock, G. (1992): High amount of e(g-glutamyl)lysine cross-links in Mallory bodies. Laboratory Investigation 66, 774-777Fésüs, L (1992): Apoptosis. Immunology Today 13, A16-17Gentile, V., Thomazy, V., Piacentini, M., Fésüs, L and Davies, P.J.A. (1992): Transfection of tissue transglutaminase into balb-c 3T3 fibroblasts: increased cellular adhesion fragmentation.Journal of Cell Biology 119, 463-474Tarcsa, E., Kedei, N., Thomazy, V. and Fésüs, L (1992): An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis. Journal of Biological Chemistry 267, 25648-25651
(1991)
Piacentini, M., Autuori, F., Dini, L., Farrace, M.G., Ghibelli, L., Piredda, L. and Fésüs, L (1991): Tissue transglutaminase is specifically expressed in neonatal rat liver cells undergoing apoptosis upon epidermal growth factor stimulation.Cell and Tissue Research 263, 227-235Fésüs, L, Tarcsa, E., Kedei, N., Autuori, F. and Piacentini, M. (1991): Degradation of cells dying by apoptosis leads to accumulation of e(g-glutamyl)lysine isodipeptide in culture fluid and blood.FEBS Letters 284, 109-112Hársfalvi, J., Fésüs, L, Tarcsa, E., Laczko, J. and Loewy, A. (1991): The presence of covalently cross-linked matrix in human platelets. Biochimica et Biophysica Acta 1073, 268-274
Piacentini, M., Thomázy, V., Tarcsa, E., Farrace, M.G., Autuori, F. and Fésüs, L (1991): Role of transglutaminase in the formation of apoptotic bodies. In "Modulating Factors in Multistage Carcinogenesis" (Columbano, A. and Pani, P. eds.). Plenum Press, New York, pp. 461-472Piacentini, M., Fésüs, L, Farrace, M.G., Ghibelli, L. and Melino, G. (1991): The expression of tissue transglutaminase in two human cancer lines is related to programmed cell death (apoptosis).European Journal of Cell Biology 54, 246-254Friedrich, P., Fésüs, L, Tarcsa, E. and Czéh, G. (1991): Protein cross-linking by transglutaminase induced in long-term potentiation in the CA1 region of hippocampal slices. Neuroscience 43, 331-334Fésüs, L (1991): Apoptosis fashions T and B cell repertoire (review). Immunology Letters 30, 277-282Davies, P.J.A., Stein, J.P., Chiocca, E.A., Basilion, J.P., Gentile, V., Thomázy, V. and Fésüs, L (1991): Retinoid-regulated expression of transglutaminase: links to the biochemistry of programmed cell death. In "Retinoids in Normal Development and Carcinogenesis" (Morris-Kay, G. ed.). Oxford University Press, pp. 249-263Fésüs, L, Davies, P.J.A. and Piacentini, M. (1991): Molecular mechanisms in the program of cell death by apoptosis (review). European Journal of Cell Biology 56, 170-177 Fésüs, L, Nagy, L., Basilion, J. and Davies, P.J.A. (1991) Retinoic acid transcripts in human umbilical vein endothelial cells. Biochemical Biophysical Research Communications 179, 32-38Reichert, U. and Fésüs, L (1991): Programmed cell death (review). Retinoids Today and Tomorrow 24, 31-34
(1990)
Tarcsa, E. and Fésüs, L (1990): Measurement of e(g-glutamyl)lysine cross-link in proteins by PITC derivatization and HPLC separation. Analytical Biochemistry 186, 135-140
(1989)
Differential expression of tissue transglutaminase in human cells: an immunohistochemical study. Cell and Tissue Research 255, 215-224Schulte-Hermann, R., Bursch, W., Fésüs, L and Kraupp, B. (1989): Cell death by apoptosis in normal, preneoplastic and neoplastic tissue. In "Chemical Carcinogenesis: Models and Mechanisms" (Feo, F., Pani, P., Columbano, A. and Garcea, R. eds.). Plenum Press New York, pp. 263-274Fésüs, L, Thomázy, V., Autuori, F., Ceru, M.P., Tarcsa, E. and Piacentini, M. (1989): Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase acton.FEBS Letters 245, 150-154Ceru, M.P., Piacentini, M., Piredda, L., Farrace, M., Autuori, F. and Fésüs, L (1989): Modulation of transglutaminase by retinoic acid in liver cells. Italian Journal of Biochemistry 38, 279-281Fésüs, L and Tarcsa, E. (1989): Formation of e(g-glutamyl)lysine isodipeptide in Chinese hamster ovary cells. Biochemical Journal 263, 843-849
(1988)
Fésüs, L and Thomázy, V. (1988): Immunohistochemical localization of tissue translgutaminase. Italian Journal of Biochemistry 37, 238-241Lee, K.N., Chung, S.I. Girard, J. and Fésüs, L (1988): Evaluation of phenylthiourea derivatives as inhibitors of transglutaminase-catalyzed reaction in Chinese hamster ovary cells. Biochimica et Biophysica Acta 972, 120-130Schulte-Hermann, R., Bursch, W., Fésüs, L, Timmermann-Trosiener, I., Kraupp, B. and Liehr, J. (1988): Role of cell death in hepatocarcinogenesis. In "Liver Cell Carcinoma" (Bannasch, P., Keppler, D. and Weber, G. eds.). Kluwer Academic Publishers, Dordecht, pp. 347-358Piacentini, M., Fésüs, L, Sartori, C. and Argento-Ceru, M.P. (1988): In vivo retinoic acid induced modulation of rat liver transglutaminase and total polyamines. Biochemical Journal 253, 33-38
(1987)
Fésüs, L, Arató, G., Kávai, M. and Yancey, S.T. (1987): Tumor growth and transglutaminases. In "Cancer and Haemostasis" (Muszbek, L. ed.). CRC Press, Boca Raton Fl., pp. 135-148
Fésüs, L, Thomázy, V. and Falus, A. (1987): Induction and activation of tissue transglutaminase during programmed cell death. FEBS Letters 224, 104-108
Fésüs, L and Thomázy, V. (1987): Searching for the function of tissue transglutaminase; its possible involvement in the biochemical pathway of programmed cell death. In "Posttranslational Modifications of Proteins and Ageing" (Zappia, L. ed.). Adv. Exp. Med. Biol. Vol. 231. Plenum Publishing Company; London, New York, 119-137
(1986)
Fésüs, L, Metsis, M.L. and Koteliansky, V. (1986): Transglutaminase sensitive glutamine residues of human plasma fibronectin revealed by studying its proteolytic fragments. European Journal of Biochemistry 154, 371-374Fésüs, L and Arató, G. (1986): Quantitation of tissue translutaminase by a sandwich ELISA system. J. Immunological Methods 94, 131-136Lee, K.N., Birckbichler, P.J. and Fésüs, L (1986): Purification of human erythrocyte transglutaminase by immunoaffinity chromatography. Preparative Biochemistry 16, 321-335Hársfalvi, J., Arató, G. and Fésüs, L (1986): Lipids associated with tissue transglutaminase. Biochimica et Biophysica Acta 923, 42-45Berényi, E., Zsindely, A., Fésüs, L, Szegedi, Gy. and Kávai, M. (1986): Acid phosphatase activimonocytes and sera of patients with Hodgkin disease. Cancer Letters 32, 219-222
(1985)
Muszbek, L., Polgár, J. and Fésüs, L (1985): Kinetic determination of blood coagulation factor XIII in plasma. Clinical Chemistry 31, 35-40 Fésüs, L, Szücs, E.F., Barrett, K.E., Metcalfe, D.D. and Folk, J.E. (1985): Activation of transglutaminase and the production of protein bound g-glutamylhistamine in stimulated mouse mast cells. Journal of Biological Chemistry 260, 13771-13778 Lee, K.N., Fésüs, L, Yancey, S.T., Girard, J. and Chung, S.I. (1985): Development of selective inhibitors of transglutaminase: phenylthiourea derivatives. Journal of Biological Chemistry 260, 14688-14694Fésüs, L, Folk, J.E. and Gorman, J.J. (1985): Synthetic glutamine peptides as substrates for the kinetic determination of blood coagulation factor XIII. Clinical Chemistry 31, 2044
(1984)
Kávai, M., Berényi, E., Zsindely, A., Szegedi, G. and Fésüs, L (1984): Monocyte activation in patients with Hodgkin's disease. International Journal of Cancer 34, 483-485Fésüs, L, Hársfalvi, J., Horváth, A. and Sándor, M. (1984): Transglutaminase and receptor signaling: concepts and realities. Molecular Immunology 21, 1161-116
(1983)
Fésüs, L, Horváth, A. and Hársfalvi, J. (1983): Interaction between tissue transglutaminase and phospholipid vesicles. FEBS Letters 155, 1-7 Sándor, M., Erdei, A., Fésüs, L and Gergely, J. (1983): IgG Fc receptors differ in sensitivity to primary amines. Immunological Letters 6, 265-269
(1982)
Fésüs, L, Erdei, A., Sándor, M. and Gergely, J. (1982): The influence of tissue transglutaminase on the function of Fc receptors. Molecular Immunology 19, 39-43Fésüs, L (1982): Transglutaminase activation: Significance in respect to immunologic phenomena. Survey of Immunological Research 1, 297-304 (guest editorial)
(1981)
Fésüs, L, Sándor, M., Horváth, I., Bagyinka, Cs., Erdei, A. and Gergely, J. (1981): Immune complex induced transglutaminase activation: its role in Fc receptor mediated transmembrane effect on peritoneal macrophages. Molecular Immunology 18, 633-638Fésüs, L, Falus, A., Erdei, A. and Laki, K. (1981): Human b2-microglobulin is a substrate of tissue transglutaminase; polimerization in solution and on the cell membrane. Journal of Cell Biology 89, 706-710
Fésüs, L, Stadler, I., Hársfalvi, J., Kovács, E. and Muszbek, L. (1981): Effect of prostaglandin I2 on platelet adhesion. Biomaterials 2, 53-54
Fésüs, L, Jelenska, M. and Kopec, M. (1981): Degradation of denatured collagen by thrombin. Thrombosis Research 22, 367-373
Fésüs, L, Muszbek, L. and Laki, K. (1981): The effect of methylglyoxal on actin. Biochemical Biophysical Research Com
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(1980)
Jelenska, M., Fésüs, L and Kopec, M. (1980): The comparative ability of plasma and tissue transglutaminases to use collagen as a substrate. Biochimica et Biophysica Acta 616, 4061-4066Hársfalvi, J., Muszbek, L., Stadler, I. and Fésüs, L (1980): Inhibition of platelet factor 3 availability by PGI2. Prostaglandins 20, 935-936
(1977)
Muszbek, L., Szabó, T. and Fésüs, L (1977): A highly sensitive method for the measurement of ATPase activity. Analytical Biochemistry 77, 286-288Muszbek, L. Fésüs, L, Szabó, T. and Hársfalvi, J. (1977): Procoagulant activity of thrombosthenin preparations. Thrombosis Research 10, 635-644Kávai, M., Csorba, S., Szabolcs, M., Jezerniczky, J., Fésüs, L and Szabó, B. (1977): Circulating antibodies in. Acta Pediatrica Acad. Sci. Hung. 18, 235-238Fésüs, L, Csaba, B. and Muszbek, L. (1977): Platelet activating factor - the trigger of haemostatic alterations in rat anaphylaxis. Clinical and Experimental Immunology 27, 512-515Kávai, M., Csorba, S., Szabolcs, M., Jezerniczky, J., Fésüs, L and Szabó, B. (1977): Association of precipitins and coeliac disease. Acta Allergologica 32, 295-305Fésüs, L and Laki, K. (1977) : Two antigenic sites of tissue transglutaminase. Biochemistry 16, 4061-4066
Muszbek, L., Fésüs, L, Ölveti, E. and Szabó, T. (1976): Cleavage of thrombosthenin A by thrombin. Evidence for the existence of two types of bovine platelet actin. Biochimica et Biophysica Acta 427, 171-177Fésüs, L and Muszbek, L. (1976): Reduced aggregability of platelets in rat anaphylaxis. Haemostasis 5, 51-56
Fésüs, L, Csaba, B. and Muszbek, L. (1976): Platelets in rat anaphylaxis. Acta Allergologica 31, 81-93Fésüs, L, Csaba, B. and Muszbek, L. (1976): Activation and consumption of Hageman factor in the anaphylactic shock of the rat. International Archives of Allergy and Applied Immunology 51, 496-506Fésüs, L and Kávai, M. (1976): The lack of detectable immune complexes in rat anaphylaxis. Acta Allergologica 31, 419-427Fésüs, L and Csongor, J. (1976): The abscence of intravascular clotting in rat anaphylaxis. Experientia 32, 1477-1478
(1975)
Sipka, S., Fésüs, L, Aradi, J., Dezsô, G. and Szilágyi, T. (1975): Local effect of single stranded polyadenylic acid on passive cutaneous anaphylaxis in mice. Agents and Actions 5, 272-273Fésüs, L and Ölveti, E. (1975): Measurement of fibrinolysis in rat system by one dimensional diffusion method. Experientia 31, 256-257Fésüs, L, Muszbek, L. and Csaba, B. (1975): Evidence of fibrinogen degradation in rat anaphylaxis. International Archives of Allergy and Applied Immunology 49, 540-547
(1974)
Fésüs, L, Ölveti, E., Csaba, B. and Muszbek, L. (1974): Fibrinolytic activity in rat anaphylaxis. Thrombosis and Diathesis Haemorrhagica. Thrombosis and Haemostasis 32, 341-349
(1972)
Muszbek, L., Fésüs, L and Csaba, B. (1972): Disturbance of blood glucose regulation in pertussis sensitized rats. Acta Allergologica 27, 257-26
Magyar nyelvű közlemények
(2004)
5. Tumpek Judit, Korponay-Szabó Ilma, Király Róbert, Csípő István, Fésüs László és Sipka Sándor (2004): A coeliakiás ellenanyagok epitóspecificitásának jlentősége a transzglutamináz autoantitestek diagnosztikus kimutatásban. Gyermekgyógyászat 4, 453-459
(1986)
3. Arató, G., Pálóczi, K., Szegedi, Gy. és Fésüs, L. (1986): Enzimvizsgálatok non-Hodgkin lymphomás és angioimmunoblasztos lymphadenopathiás betegek sejtmintáiban. Laboratóriumi Diagnosztika, XIII. 201-206
4. Arató, G., Haramura, G., Heksch, E., Zajka, G., Hársfalvi, J. és Fésüs, L. (1986): Vizsgálatok hazai gyártmányú enzimatikus GOT/GPT reagensekkel. Laboratóriumi Diagnosztika, XIII. 210-214
(1982)
2. Fésüs, L. (1982): A transzglutaminázok pathobiokémiai jelentôsége. Biokémia, VI. 122-128
(1980)
1. Fésüs, L. (1980): A prosztaciklin hatása a thrombocyta funkciókra. A Korányi Sándor Társaság Tudományos Ülései. XVII. 325-333
Patents / Találmányok:
7. Dr. Nemes Zoltán, Dr. Fésüs László: Eljárás Ne(g-glutamin)lizin izodipeptid és Ne(g-glutamin)lizin izopeptid-kötést tartalmazó peptidek, fehérjék kncentrációjának meghatásozására és az eljárás megvalósítására szolgáló kit
P0202978 (2002.09.10. szabadalmi bejelentés)
6. Dr. Aradi János, Dr. Tóth Ferenc, Dr. Fésüs László, Tôkés Szilvia, Dr. Tôzsér József, Dr. Nagy Károly, Dr. Uray Iván, Várnai Péter, Mezô Irén: "Anti-HIV activity of medicinal plant extract and its compounds with therapeutic and curative effect"
Külföldi szabadalom: PCT HU 97000 15
5. Fésüs, L., Szondy, Zs. and Reichert, U. (1997): Ligand antagonist RARg en tant qu'inhibiteur d'apoptose. Franciaországban bejegyzett nemzetközi szabadalom; OA 95219/BT.
4. Fésüs, L., Szondy, Zs. and Reichert, U. (1997): Utilisation du ligand antagoniste spécifique RARg. Franciaországban bejegyzett nemzetközi szabadalom; OA 95218/BT.
3. Fésüs, L., Haramura, G., Hársfalvi, J., Arató, G., Zajka, G., Heksch, E. és Nagy, L. (1984): Eljárás nagytisztaságú malát-dehidrogenáz és/vagy laktátdehidrogenáz enzim elôállítására. Szabadalmi szám: 25 986/85
2. Muszbek, L., Fésüs, L., Hársfalvi, J., Ozsvári, E. és Zajka, G. (1982): Eljárás foszfolipid preparátum elôállítására az aktivált parciális tromboplasztin idô meghatározására szolgáló eljáráshoz. Szabadalmi szám: 17 790/84
1. Székely, I., Lovász, P., Horváth, K., Körmöczy, P. és Fésüs, L. (1980): Eljárás 7-helyzetben szubsztituált PGI2-származékok elôállítására. Szabadalmi szám: 184 314
