Beáta Scholtz

 

Contact information:            

University of Debrecen Medical and Health Science Center

Department of Biochemistry and Molecular Biology

Debrecen, 4012

Nagyerdei krt. 98.

Hungary

 

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Phone: +36-52-411-717, ext. 55001

Fax: +36-52-314-989

 

 

 

Employment:

 

2001-             University of Debrecen Medical and Health Science Center Department of Biochemistry and Molecular Biology

 

                       Assistant Professor

 

                       Laboratory director of the Debrecen Clinical Genomics Center

Profile of the Genomics Center:  Biobanking for clinical studies, DNA sequencing, gene expression profiling using microarray and real-time quantitative PCR,  local and international technical courses for studying gene expression, real-time QPCR based MRD analysis of childhood acute lymphoblastic leukemia

 

 

1997-2001:             The Eppley Institute for Research in Cancer and Allied Diseases

 

                                University of Nebraska Medical Center, Omaha, NE (USA)

                               Postdoctoral research associate

 

1992-1997            The Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, NE (USA)

 

                               Ph.D. student

 

1990-1991            "Frédéric Joliot-Curie" National Research Institute for Radiobiology and Radiohygiene

 

                              Research fellow

 

Education:

 

1992  - 1997:                            Ph.D. degree

 

The Eppley Institute for Research in Cancer and Allied Diseases

 

University of Nebraska Medical Center, Omaha, NE (USA)

 

1985 – 1990:                            M.Sc degree

 

Eötvös Loránd University, Budapest, Hungary

 

Publications:

 

  1. Kiss F, Buslig J, Szegedi I, Scholtz B, Kappelmayer J, Kiss Cs: Early relapse after rituximab chemoimmunotherapy. Report on a patient with common acute lymphoblastic leukemia in second relapse and review of the literature. Pediatric Blood & Cancer, in press.
  2. Szollosi Z, Scholtz B, Egervari K, Nemes Z (2007): Transformed dermatofibrosarcoma proturberans: real time PCR detection of COL1A1-PDGFB fusion transcripts in sarcomatous areas.  J Clin Pathol. 60, 190-43.
  3. Kiss I, Oskolás H, Tóth R, Bouillet P, Tóth K, Fülöp A, Scholtz B, Ledent CA, Fésüs Land Szondy Z(2006): Adenosine A2A Receptor-Mediated Cell Death of Mouse Thymocytes Involves Adenylate Cyclase, Bim and is negatively regulated by Nur77. Eur J Immunol.36, 1559-71.
  4. Calpe S, Erdos E, Liao G, Wang N, Rietdijk S, Simarro M, Scholtz B, Mooney J, Lee CH, Shin MS, Rajnavolgyi E, Schatzle J, Morse HC 3rd, Terhorst C, Lanyi A. (2006) Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.Immunogenetics. 58(1):15-25.
  5. Briggs, S.D., Scholtz, B., Jacque, J.-M., Stevenson, M., and Smithgall,T.E. (2001): HIV-1 Nef promotes survival of cytokine-dependent human myeloid leukemia cells by a Stat3-dependent pathway. J.Biol. Chem.276,25605-11.
  6. Smithgall, T.E., Rogers, J.A., Peters, K.L., Li, J., Briggs, S.D., Lionberger, J.M.,  Cheng, H., Shibata, A., Scholtz, B., Schreiner, S., Dunham, N. (1998) : The c-Fes family of protein-tyrosine kinases.Crit Rev Oncog.9,43-62. 
  7. Kingsley-Kallesen, M., Johnson, L., Scholtz, B., Kelly, D., and Rizzino, A. (1997) Transcriptional regulation of the TGF-ß2 gene in choriocarcinoma cells and breast carcinoma cells: differential utilization of cis-regulatory elements.  In Vitro Cell. Dev. Biol. Anim. 33, 294-301.
  8. Scholtz, B., Kingsley-Kallesen, M., Kelly, D., and Rizzino, A. (1996) Transcription of the transforming growth factor-ß2 gene is dependent on an E-box located between an essential CRE/ATF motif and the TATA-box of the gene. J. Biol. Chem. 271, 32375-32380.
  9. Scholtz, B., Lamb, K., Rosfjord, E., Kingsley, M., and Rizzino, A. (1996) Appearance of nuclear protease activity after embryonal carcinoma cells undergo differentiation. Developmental Biology 173, 420-427.
  10. Scholtz, B., Kelly, D., and Rizzino, A. (1995) Cis-regulatory elements and transcription factors involved in the regulation of the transforming growth factor-ß2 gene. Mol. Repr. and Dev. 41, 140-148.
  11. Rosfjord, E., Scholtz, B., Lewis, R., and Rizzino, A. (1995) Phosphorylation and DNA binding of the octamer binding transcription factor Oct-3. Biochem. Biophys. Res. Comm. 212, 847-853.
  12. Kelly, D., Scholtz, B., Orten, D. J., Hinrichs, S. H., and Rizzino, A. (1995) Regulation of the transforming growth factor-ß2 gene promoter in embryonal carcinoma cells and their differentiated cells: differential utilization of transcription factors. Mol. Repr. and Dev. 40, 135-145.

Book chapter:

 Scholtz, B., and Rizzino, A. (1998): Transcriptional regulation of the transforming growth factor-ß2 gene: possible effects of toxic substances and hormones. in "Molecular Biology in Toxicology", eds. K.B. Wallace and A. Puga. Chapter title: Growth factors as candidate genes of toxicologic relevance. Pp.15-26.