Curriculum vitae



NAME: Peter Bagossi

DATE AND PLACE OF BIRTH: 1966, Hajduboszormeny, Hungary

CITIZENSHIP: Hungarian

OFFICE: Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Faculty of Medicine, Debrecen, Hungary

EDUCATION, DEGREES: BACKGROUND: AWARDS, HONORS, PROFESSIONAL RECOGNITION: MEMBERSHIPS IN PROFESSIONAL SOCIETIES: PUBLICATIONS:
  1. Motyan, J. A., Gyemant, G., Harangi, J. and Bagossi, P. (2011). Computer-aided subsite mapping of alpha-amylases. Carbohydr Res, 346, 410-415.
  2. Austin, B. P., Tozser, J., Bagossi, P., Tropea, J. E. and Waugh, D. S. (2011). The substrate specificity of Metarhizium anisopliae and Bos taurus carboxypeptidases A: Insights into their use as tools for the removal of affinity tags. Protein Expr Purif, 77, 53-61.
  3. Bagossi, P., Bander, P., Bozoki, B. and Tozser, J. (2009). Discovery and significance of new Human T-lymphotropic Viruses: HTLV-3 and HTLV-4. Expert Review of Anti-infective Therapy, 7, 1235-1249.
  4. Boross, P., Bagossi, P., Weber, I. T. and Tozser, J. (2009). Drug targets in Human T-lymphotropic virus type 1 (HTLV-1) infection. Infect Disord Drug Targets, 9, 159-171.
  5. Kokai, E., Bagossi, P. and Dombradi, V. (2008). A protein foszfatáz 1, egy sokoldalu osi enzim. Biokemia 32, 22-33.
  6. Csosz, E., Bagossi, P., Nagy, Z., Dosztanyi, Z., Simon, I. and Fesus, L. (2008). Substrate Preference of Transglutaminase 2 Revealed by Logistic Regression Analysis and Intrinsic Disorder Examination. J Mol Biol, 383, 390-402.
  7. Eizert, H., Bander, P., Bagossi, P., Sperka, T., Miklossy, G., Boross, P., Weber, I. T. and Tozser, J. (2008). Amino acid preferences of retroviral proteases for amino-terminal positions in a type-1 cleavage site. J Virol, 82, 10111-10117.
  8. Kadas, J., Boross, P., Weber, I. T., Bagossi, P., Matuz, K. and Tozser, J. (2008). C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity. Biochem J, 416, 357-364.
  9. Kakuk, A., Friedlander, E., Vereb, G. j., Toth, G., Bagossi, P., Gergely, P. and Vereb, G. (2008). Nuclear and nucleolar localization signals in PI4K230 an isoform of phosphatidylinositol 4-kinase. Exp. Cell Res., 314, 2376-2388.
  10. Miklossy, G., Tozser, J., Kadas, J., Ishima, R., Louis, J. M. and Bagossi, P. (2008). Novel macromolecular inhibitors of HIV-1 protease. Protein Eng Des Sel, 21, 453-461.
  11. Csutak, A., Silver, D. M., Tozser, J., Steiber, Z., Bagossi, P., Hassan, Z. and Berta, A. (2008). Plasminogen Activator Inhibitor in Human Tears After Laser Refractive Surgery. J. Cataract Refr. Surg., 34, 897-901.
  12. Sperka, T., Miklossy, G., Tie, Y., Bagossi, P., Zahuczky, G., Boross, P., Matuz, K., Harrison, R.W., Weber, I.T., Tozser, J. (2007) Bovine leukemia virus protease: comparison with human T-cell leukemia virus and human immunodeficiency virus proteases. J. Gen. Virol., 88, 2052-2063.
  13. Varga, A., Bagossi, P., Tozser, J., Peitl, B., Szilvassy, Z. (2007) Effect of experimental hypercholesterolemia on K channel alpha-subunit mRNA levels in rabbit hearts. Eur. J. Pharmacol., 562, 130-131.
  14. Sperka, T., Boross, P., Eizert, H., Tozser, J., Bagossi, P. (2006) Effect of mutations on the dimer stability and the pH optimum of the human foamy virus protease. Protein Engineering Design and Selection, 19, 369-375.
  15. Feher, A., Boross, P., Sperka, T., Miklossy, G., Kadas, J., Bagossi, P., Oroszlan, S., Weber, I.T., Tozser, J. (2006) Characterization of the murine leukemia virus protease and its comparison with the HIV-1 protease. J. Gen. Virol., 87, 1321-1330.
  16. Boross, P., Tozser, J., Bagossi, P. (2006) Improved purification protocol for wild-type and mutant human foamy virus proteases. Protein Expression and Purification, 46, 343-347.
  17. Sperka, T., Pitlik, J., Bagossi, P., Tozser, J. (2005) Beta-lactam compounds as uncompetitive inhibitors of HIV-1 protease. Bioorganic & Medicinal Chemistry Letters, 15, 3086-3090.
  18. Bagossi, P., Sperka, T., Feher, A., Kadas, J., Zahuczky, G., Miklossy, G., Boross, P., Tozser, J. (2005) Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites. Journal of Virology, 79, 4213-4218.
  19. Tozser, J., Tropea, J.E., Cherry, S., Bagossi, P., Copeland, T.D., Wlodawer, A., Waugh, D.S. (2005) Comparison of the substrate specificity of two potyvirus proteases. FEBS Journal, 272, 514-523.
  20. Bagossi, P., Horvath, G., Vereb, G., Szollosi, J., Tozser, J. (2005) Molecular modeling of nearly full length ErbB2 receptor. Biophysical Journal, 88, 1354-1363.
  21. Kadas, J., Weber, I.T., Bagossi, P., Miklossy, G., Boross, P., Tozser J. (2004) Alteration of the specificity of human T-cell leukemia virus type-1 protease. J. Biol. Chem., 279, 27148-27157.
  22. Bagossi, P., Kadas, J., Miklossy, G., Boross, P., Weber, I.T., Tozser J. (2004) Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases. J. Virol. Methods, 119, 87-93.
  23. Tozser, J., Shulenin, S., Kadas, J., Boross, P., Bagossi, P., Copeland, T.D., Nair, B.C., Sarngadharan, M.G., Oroszlan, S. (2003) Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis. Virology, 310, 16-23.
  24. Tozser, J., Bagossi, P., Zahuczky, G., Specht, S. I., Majerova, E., Copeland, T.D. (2003) Effect of caspase cleavage site phosphorylation on proteolysis. Biochemical Journal, 372, 137-143.
  25. Zeke, T., Kokai, E., Szoor, B., Yatzkan, E., Yarden, O., Szirak, K., Feher, Zs., Bagossi, P., Gergely, P., Dombradi, V. (2002) Expression of protein phosphatase 1 during the asexual development of Neurospora crassa. Comparative Biochemistry and Physiology Part B, 134, 161-170.
  26. Feher, A., Weber, I.T., Bagossi, P., Boross, P., Mahalingam, B., Louis, J.M., Copeland, T.D., Torshin, I.Y., Harrison, R.W., Tozser, J. (2002) Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing site. European Journal of Biochemistry, 269, 1-7.
  27. Gaspar, R.Jr., Bagossi, P., Bene, L., Matko, J., Szollosi, J., Tozser, J., Fesus, L., Waldmann, T.A., Damjanovich, S. (2001) Clustering of class I HLA oligomers with CD8 and TCR: three-dimensional models based on fluorescemce resonance energy transfer and crystallographic data. The Journal of Immunology, 166, 5078-5086.
  28. Tozser, J., Zahuczky, G., Bagossi, P., Louis, J.M., Copeland, T.D., Oroszlan, S., Harrison, R.W., Weber, I.T. (2000) Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases. European Journal of Biochemistry, 267, 1-10.
  29. Zahuczky, G., Boross, P., Bagossi, P., Emri, G., Copeland, T.D., Oroszlan, S., Louis, J.M., Tozser, J. (2000) Cloning of the bovine leukemia virus proteinase in Escherichia coli and comparison of its specificity to that of human T-cell leukemia virus proteinase. Biochimica et Biophysica Acta - Protein structure and molecular enzymology, 1478, 1-8.
  30. Fenyofalvi, G., Bagossi, P., Copeland, T.D., Oroszlan, S., Boross, P., Tozser, J. (1999) Expression and characterization of human foamy virus proteinase. FEBS Letters, 462, 397-401.
  31. Tozser, J., Bagossi, P., Boross, P., Louis, J.M., Majerova, E., Oroszlan, S., Copeland, T.D. (1999) Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates. European Journal of Biochemistry, 265, 423-429.
  32. Boross, P., Bagossi, P., Copeland, T.D., Oroszlan, S., Louis, J.M., Tozser, J. (1999) Effect of substrate residues on the P2 ' preference of retroviral proteinases. European Journal of Biochemistry, 264, 921-929.
  33. Bagossi, P., Zahuczky, G., Tozser, J., Weber, I.T. and Harrison, R.W. (1999) Improved parameters for generating partial charges: correlation with observed dipole moments. J. Mol. Model., 5, 143-152.
  34. Vissi, E., Csordas-Toth, E., Kovacs, I., Magyar, Z., Horvath, V.G., Bagossi, P., Gergely, P., Dudits, D. and Dombradi, V. (1998) Protein phosphatase 1 catalytic subunit isoforms from alfalfa: biochemical characterization and cDNA cloning. Archives of Biochemistry and Biophysics, 360, 206-214.
  35. Bagossi, P., Cheng, Y.E., Oroszlan, S. and Tozser, J. (1998) Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers. Protein Engineering, 11, 439-445.
  36. Tozser, J., Bagossi, P., Weber, I.T., Louis, J.M., Copeland, T.D., Oroszlan, S. (1997) Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity. Journal of Biological Chemistry, 272, 16807-16814.
  37. Tozser, J., Yin, F.H., Cheng, Y.E., Bagossi, P., Weber, I.T., Harrison, R.W., Oroszlan, S. (1997) Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit. European Journal of Biochemistry, 244, 235-241.
  38. Pitlik, J., Bagossi, P., Jeko, J., Tozser, J. (1996) Synthesis of cefalosporin oligopeptides as potential proteinase inhibitors. Pharmazie, 51, 700-704.
  39. Bagossi, P., Cheng, Y-S.E., Oroszlan, S., Tozser, J. (1996) Activity of linked HIV-1 proteinase dimers containing mutations in the active site region. Protein Engineering, 9, 997-1003.
  40. Tozser, J., Bagossi, P., Weber, I.T., Copeland, T.D., Oroszlan, S. (1996) Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases. Journal of Biological Chemistry, 271, 6781-6788.


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