Curriculum vitae

NAME: Peter Bagossi

DATE AND PLACE OF BIRTH: 1966, Hajduboszormeny, Hungary


OFFICE: Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Faculty of Medicine, Debrecen, Hungary

  1. Motyan, J. A., Gyemant, G., Harangi, J. and Bagossi, P. (2011). Computer-aided subsite mapping of alpha-amylases. Carbohydr Res, 346, 410-415.
  2. Austin, B. P., Tozser, J., Bagossi, P., Tropea, J. E. and Waugh, D. S. (2011). The substrate specificity of Metarhizium anisopliae and Bos taurus carboxypeptidases A: Insights into their use as tools for the removal of affinity tags. Protein Expr Purif, 77, 53-61.
  3. Bagossi, P., Bander, P., Bozoki, B. and Tozser, J. (2009). Discovery and significance of new Human T-lymphotropic Viruses: HTLV-3 and HTLV-4. Expert Review of Anti-infective Therapy, 7, 1235-1249.
  4. Boross, P., Bagossi, P., Weber, I. T. and Tozser, J. (2009). Drug targets in Human T-lymphotropic virus type 1 (HTLV-1) infection. Infect Disord Drug Targets, 9, 159-171.
  5. Kokai, E., Bagossi, P. and Dombradi, V. (2008). A protein foszfatáz 1, egy sokoldalu osi enzim. Biokemia 32, 22-33.
  6. Csosz, E., Bagossi, P., Nagy, Z., Dosztanyi, Z., Simon, I. and Fesus, L. (2008). Substrate Preference of Transglutaminase 2 Revealed by Logistic Regression Analysis and Intrinsic Disorder Examination. J Mol Biol, 383, 390-402.
  7. Eizert, H., Bander, P., Bagossi, P., Sperka, T., Miklossy, G., Boross, P., Weber, I. T. and Tozser, J. (2008). Amino acid preferences of retroviral proteases for amino-terminal positions in a type-1 cleavage site. J Virol, 82, 10111-10117.
  8. Kadas, J., Boross, P., Weber, I. T., Bagossi, P., Matuz, K. and Tozser, J. (2008). C-terminal residues of mature human T-lymphotropic virus type 1 protease are critical for dimerization and catalytic activity. Biochem J, 416, 357-364.
  9. Kakuk, A., Friedlander, E., Vereb, G. j., Toth, G., Bagossi, P., Gergely, P. and Vereb, G. (2008). Nuclear and nucleolar localization signals in PI4K230 an isoform of phosphatidylinositol 4-kinase. Exp. Cell Res., 314, 2376-2388.
  10. Miklossy, G., Tozser, J., Kadas, J., Ishima, R., Louis, J. M. and Bagossi, P. (2008). Novel macromolecular inhibitors of HIV-1 protease. Protein Eng Des Sel, 21, 453-461.
  11. Csutak, A., Silver, D. M., Tozser, J., Steiber, Z., Bagossi, P., Hassan, Z. and Berta, A. (2008). Plasminogen Activator Inhibitor in Human Tears After Laser Refractive Surgery. J. Cataract Refr. Surg., 34, 897-901.
  12. Sperka, T., Miklossy, G., Tie, Y., Bagossi, P., Zahuczky, G., Boross, P., Matuz, K., Harrison, R.W., Weber, I.T., Tozser, J. (2007) Bovine leukemia virus protease: comparison with human T-cell leukemia virus and human immunodeficiency virus proteases. J. Gen. Virol., 88, 2052-2063.
  13. Varga, A., Bagossi, P., Tozser, J., Peitl, B., Szilvassy, Z. (2007) Effect of experimental hypercholesterolemia on K channel alpha-subunit mRNA levels in rabbit hearts. Eur. J. Pharmacol., 562, 130-131.
  14. Sperka, T., Boross, P., Eizert, H., Tozser, J., Bagossi, P. (2006) Effect of mutations on the dimer stability and the pH optimum of the human foamy virus protease. Protein Engineering Design and Selection, 19, 369-375.
  15. Feher, A., Boross, P., Sperka, T., Miklossy, G., Kadas, J., Bagossi, P., Oroszlan, S., Weber, I.T., Tozser, J. (2006) Characterization of the murine leukemia virus protease and its comparison with the HIV-1 protease. J. Gen. Virol., 87, 1321-1330.
  16. Boross, P., Tozser, J., Bagossi, P. (2006) Improved purification protocol for wild-type and mutant human foamy virus proteases. Protein Expression and Purification, 46, 343-347.
  17. Sperka, T., Pitlik, J., Bagossi, P., Tozser, J. (2005) Beta-lactam compounds as uncompetitive inhibitors of HIV-1 protease. Bioorganic & Medicinal Chemistry Letters, 15, 3086-3090.
  18. Bagossi, P., Sperka, T., Feher, A., Kadas, J., Zahuczky, G., Miklossy, G., Boross, P., Tozser, J. (2005) Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites. Journal of Virology, 79, 4213-4218.
  19. Tozser, J., Tropea, J.E., Cherry, S., Bagossi, P., Copeland, T.D., Wlodawer, A., Waugh, D.S. (2005) Comparison of the substrate specificity of two potyvirus proteases. FEBS Journal, 272, 514-523.
  20. Bagossi, P., Horvath, G., Vereb, G., Szollosi, J., Tozser, J. (2005) Molecular modeling of nearly full length ErbB2 receptor. Biophysical Journal, 88, 1354-1363.
  21. Kadas, J., Weber, I.T., Bagossi, P., Miklossy, G., Boross, P., Tozser J. (2004) Alteration of the specificity of human T-cell leukemia virus type-1 protease. J. Biol. Chem., 279, 27148-27157.
  22. Bagossi, P., Kadas, J., Miklossy, G., Boross, P., Weber, I.T., Tozser J. (2004) Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases. J. Virol. Methods, 119, 87-93.
  23. Tozser, J., Shulenin, S., Kadas, J., Boross, P., Bagossi, P., Copeland, T.D., Nair, B.C., Sarngadharan, M.G., Oroszlan, S. (2003) Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis. Virology, 310, 16-23.
  24. Tozser, J., Bagossi, P., Zahuczky, G., Specht, S. I., Majerova, E., Copeland, T.D. (2003) Effect of caspase cleavage site phosphorylation on proteolysis. Biochemical Journal, 372, 137-143.
  25. Zeke, T., Kokai, E., Szoor, B., Yatzkan, E., Yarden, O., Szirak, K., Feher, Zs., Bagossi, P., Gergely, P., Dombradi, V. (2002) Expression of protein phosphatase 1 during the asexual development of Neurospora crassa. Comparative Biochemistry and Physiology Part B, 134, 161-170.
  26. Feher, A., Weber, I.T., Bagossi, P., Boross, P., Mahalingam, B., Louis, J.M., Copeland, T.D., Torshin, I.Y., Harrison, R.W., Tozser, J. (2002) Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing site. European Journal of Biochemistry, 269, 1-7.
  27. Gaspar, R.Jr., Bagossi, P., Bene, L., Matko, J., Szollosi, J., Tozser, J., Fesus, L., Waldmann, T.A., Damjanovich, S. (2001) Clustering of class I HLA oligomers with CD8 and TCR: three-dimensional models based on fluorescemce resonance energy transfer and crystallographic data. The Journal of Immunology, 166, 5078-5086.
  28. Tozser, J., Zahuczky, G., Bagossi, P., Louis, J.M., Copeland, T.D., Oroszlan, S., Harrison, R.W., Weber, I.T. (2000) Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases. European Journal of Biochemistry, 267, 1-10.
  29. Zahuczky, G., Boross, P., Bagossi, P., Emri, G., Copeland, T.D., Oroszlan, S., Louis, J.M., Tozser, J. (2000) Cloning of the bovine leukemia virus proteinase in Escherichia coli and comparison of its specificity to that of human T-cell leukemia virus proteinase. Biochimica et Biophysica Acta - Protein structure and molecular enzymology, 1478, 1-8.
  30. Fenyofalvi, G., Bagossi, P., Copeland, T.D., Oroszlan, S., Boross, P., Tozser, J. (1999) Expression and characterization of human foamy virus proteinase. FEBS Letters, 462, 397-401.
  31. Tozser, J., Bagossi, P., Boross, P., Louis, J.M., Majerova, E., Oroszlan, S., Copeland, T.D. (1999) Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates. European Journal of Biochemistry, 265, 423-429.
  32. Boross, P., Bagossi, P., Copeland, T.D., Oroszlan, S., Louis, J.M., Tozser, J. (1999) Effect of substrate residues on the P2 ' preference of retroviral proteinases. European Journal of Biochemistry, 264, 921-929.
  33. Bagossi, P., Zahuczky, G., Tozser, J., Weber, I.T. and Harrison, R.W. (1999) Improved parameters for generating partial charges: correlation with observed dipole moments. J. Mol. Model., 5, 143-152.
  34. Vissi, E., Csordas-Toth, E., Kovacs, I., Magyar, Z., Horvath, V.G., Bagossi, P., Gergely, P., Dudits, D. and Dombradi, V. (1998) Protein phosphatase 1 catalytic subunit isoforms from alfalfa: biochemical characterization and cDNA cloning. Archives of Biochemistry and Biophysics, 360, 206-214.
  35. Bagossi, P., Cheng, Y.E., Oroszlan, S. and Tozser, J. (1998) Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers. Protein Engineering, 11, 439-445.
  36. Tozser, J., Bagossi, P., Weber, I.T., Louis, J.M., Copeland, T.D., Oroszlan, S. (1997) Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity. Journal of Biological Chemistry, 272, 16807-16814.
  37. Tozser, J., Yin, F.H., Cheng, Y.E., Bagossi, P., Weber, I.T., Harrison, R.W., Oroszlan, S. (1997) Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit. European Journal of Biochemistry, 244, 235-241.
  38. Pitlik, J., Bagossi, P., Jeko, J., Tozser, J. (1996) Synthesis of cefalosporin oligopeptides as potential proteinase inhibitors. Pharmazie, 51, 700-704.
  39. Bagossi, P., Cheng, Y-S.E., Oroszlan, S., Tozser, J. (1996) Activity of linked HIV-1 proteinase dimers containing mutations in the active site region. Protein Engineering, 9, 997-1003.
  40. Tozser, J., Bagossi, P., Weber, I.T., Copeland, T.D., Oroszlan, S. (1996) Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases. Journal of Biological Chemistry, 271, 6781-6788.

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