The Structural Biology and Bioinformatics Group (SBBG) was established in 2004 as part of the Laboratory of Retroviral Biochemistry (LRB). Currently the group has 2 active members: Dr. Peter Bagossi (leader), and Janos Motyan (PhD student). Former group members were Dr. Janos Roszik (Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen), Gabor Guta (PhD student) and Csaba Grepaly (graduate student).

Our major research interest is to study the retroviral proteases using molecular modeling techniques and bioinformatical approach with strong collaboration of the other groups of LRB. We also support other research activities of LRB members by the aid of various computational techniques, including in-house programs: Homolog Model Maker (HoMoMa), HoSeq (for calculation of sequence identity and similarity), Hydrophob, LegoFret, TMHelix, rotate_pdb_ab, rotate_pdb_xyz, translate_pdb, AtomDist, SeqStat,

Examples of oligonucleotide primers used in our lab:

We also studied the membrane surface association patterns of MHC and ErbB receptors in collaboration with Prof. Rezso Gaspar and Prof. Janos Szollosi (Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen). Structural features of protein phosphatases were studied in collaboration with Prof. Viktor Dombradi (Department of Medical Chemistry, Faculty of Medicine, University of Debrecen). Potyviral proteases were modeled in collaboration with Dr. David Waugh (NCI-Frederick, USA). Transglutaminases are studied in collaboration with the research group of Prof. Laszlo Fesus (Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen). Alpha-amylases are studied in collaboration with Dr. Janos Harangi (Department of Biochemistry, Institute of Biology, University of Debrecen).